Drug interactions may possibly change how your medicines operate or boost your possibility for severe Negative effects. This doc won't comprise all probable drug interactions.
Although it helps Lots of individuals, this medication incorporates a possibility for abuse and should sometimes result in dependancy. This possibility could possibly be bigger Should you have a substance use problem (like overuse of or dependancy to medicines/Liquor).
For example, a lot of noted circumstances of death transpired within the put up operative interval following tonsillectomy and/or adenoidectomy, and plenty of of the youngsters had evidence of staying ultra-rapid metabolizers of codeine. Also, kids with obstructive sleep apnea who will be addressed with codeine for publish-tonsillectomy and/or adenoidectomy ache could possibly be significantly delicate to its respiratory depressant influence. Due to hazard of everyday living-threatening respiratory despair and Demise:
Using Promethazine with Codeine Oral Resolution in individuals with acute or intense bronchial asthma within an unmonitored setting or inside the absence of resuscitative equipment is contraindicated [seeCONTRAINDICATIONS (four)]. Opioid analgesics and antitussives, such as codeine, among the Lively components in Promethazine with Codeine Oral Solution, shouldn't be Employed in people with acute febrile sickness affiliated with successful cough or in patients with Long-term respiratory ailment the place interference with ability to very clear the tracheobronchial tree of secretions would've a deleterious impact on the patient's respiratory perform.
Codeine produces peripheral vasodilation which can bring about orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation may well involve pruritus, flushing, red eyes and perspiring and/or orthostatic hypotension.
In case you are prescribed this medication on an everyday program and miss out on a dose, consider it once you keep in mind. If it is near the time of the subsequent dose, skip the missed dose. Acquire your next dose on the typical time. Tend not to double the dose to catch up.
Promethazine with Codeine Oral Solution should be used with warning in people with bone-marrow despair. Leukopenia and agranulocytosis are described, normally when promethazine has become Utilized in association with other recognised marrow-poisonous agents.
An elevated chance of particular malformations with codeine publicity including respiratory malformations, spina bifida and congenital coronary heart defects had been claimed in a few research.
An opioid antagonist, including naloxone, has to be readily available for reversal of opioid-induced respiratory melancholy inside the neonate. Opioids, which includes Promethazine with Codeine Oral Alternative, can extend labor by steps which quickly lessen the strength, period, and frequency of uterine contractions. Even so, this outcome isn't consistent and may be offset by an increased rate of cervical dilation, which has a tendency to shorten labor. Observe neonates subjected to opioids during labor for indications of extra sedation and respiratory depression.
Because of the chance of respiratory despair, steer clear of the use of opioid here antitussives, which include Promethazine with Codeine Oral Alternative in individuals with compromised respiratory operate, clients liable to respiratory failure, and in elderly, cachectic, or debilitated individuals.
Cytochrome P450 2D6 is the main enzyme to blame for conversion of codeine to morphine and P450 3A4 is the major enzyme mediating conversion of codeine to norcodeine. Morphine and norcodeine are even further metabolized by conjugation with glucuronic acid. The glucuronide metabolites of morphine are morphine-three-glucuronide (M3G) and morphine-six-glucuronide (M6G). Morphine and its M6 glucuronide conjugate are pharmacologically active. No matter whether C6G has pharmacological exercise is unknown. Norcodeine and M3 glucuronide conjugate of morphine are normally not thought to be pharmacologically Energetic.
A house teaspoon is just not an correct measuring device and could lead on to overdosage. For prescriptions exactly where a measuring product just isn't delivered, a pharmacist can provide an ideal measuring gadget and can offer instructions for measuring the right dose. Never overfill. Rinse the measuring unit with h2o after Just about every use.
Codeine generates respiratory melancholy by direct action on Mind stem respiratory facilities. The respiratory melancholy includes a discount while in the responsiveness on the brain stem respiratory centers to each increases in carbon dioxide tension also to electrical stimulation.
The dosage of Promethazine with Codeine Oral Answer shouldn't be enhanced if cough fails to reply; an unresponsive cough need to be reevaluated for feasible underlying pathology.